CD20 Antibody [2H7] (APC)

Product Specifications

Background

The 2H7 monoclonal antibody specifically reacts with human CD20, a 33-37kDA B-lymphocyte surface molecule. CD20 is an unglycosylated four-transmembrane phosphoprotein expressed by B cells in all stage of development, except the final plasma cells. It has been reported that the molecule is involved in B cell activation and has also been observed on a subset of circulating T lymphocytes.

NCBI Gene ID

931

Swiss Prot

P11836

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

2H7

Conjugation

APC

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG2b, kappa

Specificity

The 2H7 monoclonal antibody specifically reacts with human CD20, a 33-37kDA B-lymphocyte surface molecule.

Symbol

MS4A1

NCBI Official Name

Membrane-spanning 4-domains, subfamily A, member 1

NCBI Organism

Homo sapiens

Background Reference 01

Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

Background Reference 02

Polyak, M. J., Deans, J. P. (2002) . Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes

Background Reference 03

Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.