IL-20 Receptor 2 Antibody [20RNTC]

Product Specifications

Background

The 20RNTC monoclonal antibody specifically reacts with human and mouse interleukin-20 receptor 2 (IL-20R2 or IL-20Rb) . IL-20R2 is a class II cytokine receptor that pairs with IL-20R to form a receptor capable of binding IL-19, IL-20, or IL-24 and binds IL-20, or IL-24 when paired with IL-22R1. It is primarily found on epithelial originated cells such as those found in the skin or intestines.

NCBI Gene ID

53833;213208

Swiss Prot

Q6UXL0

Host

Rat

Reactivity

Human, Mouse

Clonality

Monoclonal

Clone

20RNTC

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Rat IgG2a, kappa

Specificity

The 20RNTC monoclonal antibody specifically reacts with human and mouse interleukin-20 receptor 2 (IL-20R2 or IL-20Rb) .

Symbol

IL20RB

NCBI Official Name

Interleukin 20 receptor beta

NCBI Organism

Homo sapiens; Mus musculus

Background Reference 01

Blumberg, H., Conklin, D., Xu, W., Grossmann, A., Brender, T., Carollo, S., ... Chandrasekher, Y. A. (2001) . Interleukin 20: discovery, receptor identification, and role in epidermal function.Cell,104 (1), 9-19.

Background Reference 02

Wahl, C., M, W., Leith, F., Adler, G., Oswald, F., Reimann, J., ... Wegenka, U. M. (2009) . IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses.The Journal of Immunology,182 (2), 802-810.

Background Reference 03

Dumoutier, L., Leemans, C., Lejeune, D., Kotenko, S. V., Renauld, J. C. (2001) . Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types.The Journal of Immunology,167 (7), 3545-3549.