IGF 1R (phospho Tyr1165 / Tyr1166) Antibody

Product Specifications

Background

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

NCBI Gene ID

3480

Swiss Prot

P08069

Accession Number

NP_000866.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

IGF-1R (Phospho-Tyr1165/Tyr1166) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-Y (p) -Y (p) -R-K) derived from Human IGF-1R .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

200, 95 kDa

Specificity

This antibody detects endogenous level of IGF-1R onlywhen phosphorylated at tyrosine 1165/tyrosine1166.

Applications Notes

Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Symbol

IGF1R

NCBI Official Name

Insulin-like growth factor 1 receptor

NCBI Organism

Homo sapiens

Background Reference 01

Li S, et al. (1994) J Biol Chem; 269 (51) : 32558-64.

Other Product Names

IGFR, CD221, IGFIR, JTK13, RAB5, Insulin-like growth factor I receptor, IGF1R, kinase IGF1R

Tested Applications

WB, IF

Protein ID

4557665

Physical Properties

Liquid

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