HER2 (phospho Tyr1221 / Tyr1222) Antibody

Product Specifications

Background

Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.

NCBI Gene ID

2064

Swiss Prot

P04626

Accession Number

NP_001005862.1

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

HER2 (Phospho-Tyr1221/Tyr1222) antibody was raised against a peptide sequence around phosphorylation site of tyrosine1221/1222 (N-L-Y (p) -Y (p) -W) derived from Human HER2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

185 kDa

Specificity

This antibody detects endogenous level of HER2 only when phosphorylated at tyrosine1221/tyrosine1222.

Applications Notes

Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Symbol

ERBB2

NCBI Official Name

V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

NCBI Organism

Homo sapiens

Background Reference 01

Marone R, et al. (2004) Nat Cell Biol; 6 (6) : 515-22. Ren Z, et al. (2002) J Biol Chem; 277 (41) : 38486-93.

Other Product Names

NEU, NGL, HER2, TKR1, CD340, HER-2, MLN19, HER-2/neu, GP3A, C-erbB-2, ErbB2

Tested Applications

WB, IF

Protein ID

54792098

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

123002 50 µg

ADH1C (Alcohol Dehydrogenase 1C, Alcohol Dehydrogenase Subunit gamma, ADH3)

Ask

View Details

345520-01 100 µL

Rab 18 discontinued

Ask

View Details

345520-02 200 µL

Rab 18 discontinued

Ask

View Details

MBS2100938-01 5x 96 Tests

Mouse Coagulation Factor XI (F11) Antibody Pair Kit (with Standard)

Ask

View Details

MBS2100938-02 5x 96 Tests + MBS2090685 (Ab Pairs Support Pack 1,5x 96 Tests)

Mouse Coagulation Factor XI (F11) Antibody Pair Kit (with Standard)

Ask

View Details

MBS2100938-03 10x 96 Tests

Mouse Coagulation Factor XI (F11) Antibody Pair Kit (with Standard)

Ask

View Details