P95 / NBS1 (phospho Ser343) Antibody
Product Specifications
Background
Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
NCBI Gene ID
4683
Swiss Prot
O60934
Accession Number
NP_002476.2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
P95/NBS1 (Phospho-Ser343) antibody was raised against a peptide sequence around phosphorylation site of serine 343 (S-L-S (p) -Q-G) derived from Human p95/NBS1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific, Cell Cycle
Purification
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
95 kDa
Specificity
This antibody detects endogenous level of p95/NBS1 only when phosphorylated at serine 343.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
NBN
NCBI Official Name
Nibrin
NCBI Organism
Homo sapiens
Background Reference 01
Hsu HL, et al (2005) Oncogene; 24 (31) : 4956-64. Falck J, et al. (2005) Nature; 434 (7033) : 605-11. Buscemi G, et al. (2004) Oncogene; 23 (46) : 7691-700. Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A; 101 (33) : 12130-5.
Other Product Names
ATV, NBS, P95, NBS1, AT-V1, AT-V2, TCF5, PP9092
Tested Applications
WB
Protein ID
33356172
Physical Properties
Liquid
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