C kit (Ab 936) Antibody

Product Specifications

Background

This is the receptor for stem cell factor (mast cell growth factor) . It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K)

NCBI Gene ID

3815

Swiss Prot

P10721

Accession Number

NP_000213.1

Host

Rabbit

Reactivity

Human

Immunogen

C-kit (Ab-936) antibody was raised against a peptide sequence around aa.934~938 (H-I-Y-S-N) derived from Human c-Kit.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

145 kDa

Specificity

This antibody detects endogenous level of total c-Kit protein.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

KIT

NCBI Official Name

V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

NCBI Organism

Homo sapiens

Background Reference 01

Martin, F. H. et al. (1990) Cell 63, 203-11. Blume-Jensen, P. et al. (2000) Nat Genet 24, 157-62. Gommerman, J. L. et al. (1997) J Biol Chem 272, 30519-25. Nocka, K. et al. (1990) EMBO J 9, 1805-13.