PLC gamma2 (Ab 1217) Antibody

Product Specifications

Background

The production of the second messenger molecules diacylglycerol. (DAG) and inositol 1, 4, 5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

NCBI Gene ID

5336

Swiss Prot

P16885

Accession Number

NP_002652.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

PLC-gamma2 (Ab-1217) antibody was raised against a peptide sequence around aa.1215~1219 (F-L-Y-D-T) derived from Human PLCγ2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

150 kDa

Specificity

This antibody detects endogenous level of total PLC-γ2 protein.

Applications Notes

Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

Symbol

PLCG2

NCBI Official Name

Phospholipase C, gamma 2 (phosphatidylinositol-specific)

NCBI Organism

Homo sapiens

Background Reference 01

Singer, W. D. et al. (1997) Annu. Rev. Biochem. 66, 475-509. Smrcka, A. V. et al. (1991) Science 251, 804-807. Yue, C. et al. (2000) J. Biol. Chem. 275, 30220-30225. Watanabe, D. et al. (2001) J. Biol. Chem. 276, 38595-38601.