IGF 1R (Ab 1346) Antibody

Product Specifications

Background

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

NCBI Gene ID

3480

Swiss Prot

P08069

Accession Number

NP_000866.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

IGF-1R (Ab-1346) antibody was raised against a peptide sequence around aa.1344~1348 (Q-P-Y-A-H) derived from Human IGF-1R .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

200, 95 kDa

Specificity

This antibody detects endogenous level of total IGF-1R protein.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

IGF1R

NCBI Official Name

Insulin-like growth factor 1 receptor

NCBI Organism

Homo sapiens

Background Reference 01

Adams, T. E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093Baserga, R. et al. (2000) Oncogene 19, 5574-5581Scheidegger, K. J. et al. (2000) J. Biol. Chem. 275, 38921-38928. O'Connor R, et al. Mol Cell Biol 1997 Jan; 17 (1) : 427-35