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BIM (Ab 69) Antibody

Product Specifications

Background

Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.

NCBI Gene ID

10018

Swiss Prot

O43521

Accession Number

NP_006529.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

BIM (Ab-69) antibody was raised against a peptide sequence around aa.67~71 (P-A-S-P-G) derived from Human BIM.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

23 kDa

Specificity

This antibody detects endogenous level of total BIM protein.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

BCL2L11

NCBI Official Name

BCL2-like 11 (apoptosis facilitator)

NCBI Organism

Homo sapiens

Background Reference 01

Fukazawa H, et al. (2004) Mol Cancer Ther ; 3 (10) : 1281-1288Luciano F, et al. (2003) Oncogene ; 22 (43) : 6785-6793

Other Product Names

BAM, BIM, BOD, GLNS, BCL2-like protein 11, BCL2L11, Bcl-2 related ovarian death protein

Tested Applications

WB, IHC

Protein ID

5729740

Physical Properties

Liquid

Curated Selection

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