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AMPKa1 / AMPKa2 (Ab 174 / 172) Antibody

Product Specifications

Background

Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.

NCBI Gene ID

5562;5563

Swiss Prot

Q13131

Accession Number

NP_006242.5; NP_006243.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

AMPKa1/AMPKa2 (Ab-174/172) antibody was raised against a peptide sequence around aa. 172~176/170~174 (L-R-T-S-C) derived from Human AMPKα1/AMPKα2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=79-357

Calculated Molecular Weight

63 kDa

Specificity

This antibody detects endogenous level of total AMPKα1/AMPKα2 protein.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

Symbol

PRKAA1 PRKAA2

NCBI Official Name

Protein kinase, AMP-activated, alpha 1 catalytic subunit / protein kinase, AMP-activated, alpha 2 catalytic subunit

NCBI Organism

Homo sapiens

Background Reference 01

Hurley RL, et al. (2005) J Biol Chem. Aug 12; 280 (32) : 29060-29066Woods A, et al. (2003) Curr Biol. Nov 11; 13 (22) : 2004-2008Nielsen JN, et al. (2003) J Appl Physiol. Feb; 94 (2) : 631-641Da Silva Xavier G, et al. (2000) Proc Natl Acad Sci U S A. Apr 11; 97 (8) : 4023-4028.

Other Product Names

AMPK, AMPKa1, MAPTL, MTBT1, TAU

Tested Applications

WB, IHC, IF

Protein ID

94557301 / 46877068

Physical Properties

Liquid

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