HER2 (Ab 877) Antibody

Product Specifications

Background

Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.

NCBI Gene ID

2064

Swiss Prot

P04626

Accession Number

NP_001005862.1

Host

Rabbit

Reactivity

Human

Immunogen

HER2 (Ab-877) antibody was raised against a peptide sequence around aa.875~879 (T-E-Y-H-A) derived from Human HER2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

185 kDa

Specificity

This antibody detects endogenous level of total HER2 protein.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

ERBB2

NCBI Official Name

V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

NCBI Organism

Homo sapiens

Background Reference 01

Dittadi, R. et al. (2000) J. Natl. Cancer Inst. 92, 1443-1444. Muthuswamy, S. K. et al. (1999) Mol. Cell. Biol. 19, 6845-6857. Qian, X. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 1500-1504. Kwon, Y. K. et al. (1997) J. Neurosci. 17, 8293-8299. Klapper, L. N. et al. (2000) Cancer Res. 60, 3384-3388.