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NFkB p100 / p52 (Ab 870) Antibody

Product Specifications

Background

NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-κ -B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-κ -B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth.

NCBI Gene ID

4791

Swiss Prot

Q00653

Accession Number

NP_001070961.1

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

NFkB-p100/p52 (Ab-870) antibody was raised against a peptide sequence around aa.868~872 (Y-G-S-Q-S) derived from Human NFκ B-p100/p52.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=79-266

Calculated Molecular Weight

120 kDa

Specificity

This antibody detects endogenous level of total NFκ B-p100/p52 protein.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

NFKB2

NCBI Official Name

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

NCBI Organism

Homo sapiens

Background Reference 01

Qu Z, et al. (2004) J Biol Chem; 279 (43) : 44563-72. Xiao G, et al. (2001) J Biol Chem 7 (2) : 401-9.

Other Product Names

P52, p105, H2TF1, LYT10, CVID10, LYT-10, NF-kB2, FKHR, FOXO1A, DNA-binding factor KBF2, Lymphocyte translocation chromosome 10, Lyt10, NFKB2

Tested Applications

WB, IHC

Protein ID

117320540

Physical Properties

Liquid

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