CREB (phospho Ser129) Antibody
Product Specifications
Background
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.
NCBI Gene ID
1385
Swiss Prot
P16220
Accession Number
NP_004370.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
CREB (Phospho-Ser129) antibody was raised against a peptide sequence around phosphorylation site of serine 129 (I-L-S (p) -R-R) derived from Human CREB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific, Apoptosis, Cancer, Neuroscience
Purification
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=79-222
Calculated Molecular Weight
43 kDa
Specificity
This antibody detects endogenous level of CREB only when phosphorylated at serine 129.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Symbol
CREB1
NCBI Official Name
CAMP responsive element binding protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Chrystelle V. Garat, et al. (2006) Mol. Cell. Biol ; 26: 4934 - 4948. Lilah Rothem, et al. (2004) Mol. Pharmacol ; 66: 1536 - 1543. Darren R. Tyson, et, al. (2002) Endocrinology; 143: 674. Kyung-Woo Park, et al. (2003) Arterioscler. Thromb. Vasc. Biol ; 23: 1364.
Other Product Names
CREB, HSP90B, HSPC2, HSPCB, CREB-1, CREB1
Tested Applications
WB, IHC
Protein ID
4758054
Physical Properties
Liquid
Curated Selection
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