Histone H3.1 (phospho Ser10) Antibody

Product Specifications

Background

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

NCBI Gene ID

8351

Swiss Prot

P68431

Accession Number

NP_003521.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Histone H3.1 (Phospho-Ser10) antibody was raised against a peptide sequence around phosphorylation site of serine 10 (R-K-S (p) -T-G) derived from Human Histone H3.1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific

Purification

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

17 kDa

Specificity

This antibody detects endogenous level of Histone H3.1 onlywhen phosphorylated at serine 10.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

Symbol

HIST1H3D

NCBI Official Name

Histone cluster 1, H3d

NCBI Organism

Homo sapiens

Background Reference 01

Dai J, et al. (2005) Genes Dev 19 (4) : 472-488. Yih LH, et al. (2005) Carcinogenesis 26 (1) : 53-63.

Other Product Names

H3/b, H3FB, ERBB, ERBB1, HER1, H3/a, H3/c, H3/d, H3/f, H3/h

Tested Applications

WB, IHC, IF

Protein ID

21071021

Physical Properties

Liquid

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