VASP (phospho Ser239) Antibody
Product Specifications
Background
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation.
NCBI Gene ID
7408
Swiss Prot
P50552
Accession Number
NP_003361.1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
VASP (Phospho-Ser239) antibody was raised against a peptide sequence around phosphorylation site of serine 238 (K-V-S (p) -K-Q) derived from Human VASP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=79-178
Calculated Molecular Weight
50 kDa
Specificity
This antibody detects endogenous level of VASP only when phosphorylated at serine 239.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Symbol
VASP
NCBI Official Name
Vasodilator-stimulated phosphoprotein
NCBI Organism
Homo sapiens
Background Reference 01
Wang HG, et al. (2005) euron; 45 (3) : 389-403. Melichar VO, et al. (2004) Proc Natl Acad Sci U S A; 101 (47) : 16671-6. Jensen BO, et al. (2004) Blood; 104 (9) : 2775-82. Zhuang S, et al. (2004) J Biol Chem; 279 (11) : 10397-407. Smolenski A, et al. (1998) J Biol Chem; 273 (32) : 20029-35. Butt E, et al. (1994) J Biol Chem; 269 (20) : 14509-17.
Other Product Names
NFKB3
Tested Applications
WB, IHC
Protein ID
4507869
Physical Properties
Liquid
Curated Selection
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