JAK2 (phospho Tyr1007) Antibody

Product Specifications

Background

Plays a role in leptin signaling and control of body weight

NCBI Gene ID

3717

Swiss Prot

O60674

Accession Number

NP_004963.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

JAK2 (Phospho-Tyr1007) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1007 (K-E-Y (p) -Y-K) derived from Human JAK2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific, Apoptosis, Cancer

Purification

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

125 kDa

Specificity

This antibody detects endogenous level of JAK2 only when phosphorylated at tyrosine 1007.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Symbol

JAK2

NCBI Official Name

Janus kinase 2

NCBI Organism

Homo sapiens

Background Reference 01

James C, et al. (2005) Nature. 434 (7037) : 1144-1148. Argetsinger LS, et al. (2004) Mol Cell Biol. 24 (11) : 4955-4967. Ungureanu D, et al. (2002) Mol Cell Biol. 22 (10) : 3316-3326. Xie S, et al. (2001) Oncogene. 20 (43) : 6188-6195.