HDAC8 (phospho Ser39) Antibody
Product Specifications
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC8 gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
55869
Swiss Prot
Q9BY41
Accession Number
NP_001159890.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
HDAC8 (Phospho-Ser39) antibody was raised against a peptide sequence around phosphorylation site of serine 39 (R-A-S (p) -M-V) derived from Human HDAC8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific, Cell Cycle
Purification
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
42 kDa
Specificity
This antibody detects endogenous level of HDAC8 only when phosphorylated at serine 39.
Applications Notes
Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Symbol
HDAC8
NCBI Official Name
Histone deacetylase 8
NCBI Organism
Homo sapiens
Background Reference 01
Lee H, et al. (2004) Mol Cell Biol. 24 (2) : 765-773.
Other Product Names
HD8, WTS, RPD3, CDA07, CDLS5, MRXS6, HDACL1, MAPKAPK1A, RSK1, HD8, HDA8
Tested Applications
IHC, IF
Protein ID
262073088
Physical Properties
Liquid
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