Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Tau (phospho Ser404) Antibody

Product Specifications

Background

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

NCBI Gene ID

4137

Swiss Prot

P10636

Accession Number

NP_001116538.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Tau (Phospho-Ser404) antibody was raised against a peptide sequence around phosphorylation site of serine 404 (D-T-S (p) -P-R) derived from Human Tau.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific, Neuroscience

Purification

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=79-153

Calculated Molecular Weight

48, 62, 78 kDa

Specificity

This antibody detects endogenous level of Tau only when phosphorylated at serine 404.

Applications Notes

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

Symbol

MAPT

NCBI Official Name

Microtubule-associated protein tau

NCBI Organism

Homo sapiens

Background Reference 01

Li G, Yin H, et. al . (2004) J Biol Chem ; 279 (16) : 15938-45. Noble W, et al. (2003) Neuron ; 38 (4) : 555-65. Giasson BI, et al. (2002) . Biochemistry; 41 (51) : 15376-87. Lee G., et. al. (1989) . Neuron 2:1615-1624. Andreadis A. et. al. (1992) Biochemistry 31:10626-10633.

Other Product Names

TAU, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1, MAPT, MTAPT, Neurofibrillary tangle protein, PHF-tau

Tested Applications

WB, IHC, IF

Protein ID

178557734

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Kir3dl2 Mouse siRNA Oligo Duplex (Locus ID 245615)
SR413026 1 Kit

Kir3dl2 Mouse siRNA Oligo Duplex (Locus ID 245615)

Ask
View Details
Kcnk16-set siRNA/shRNA/RNAi Lentivector (Mouse)
25396094 4 x 500 ng

Kcnk16-set siRNA/shRNA/RNAi Lentivector (Mouse)

Ask
View Details
Rabbit Tendon Fibroblast Medium
ARM0815 1 Kit

Rabbit Tendon Fibroblast Medium

Ask
View Details
Recombinant Gloeobacter violaceus Heat-inducible transcription repressor HrcA (hrcA)
MBS1398395-01 0.02 mg (E-Coli)

Recombinant Gloeobacter violaceus Heat-inducible transcription repressor HrcA (hrcA)

Ask
View Details
Recombinant Gloeobacter violaceus Heat-inducible transcription repressor HrcA (hrcA)
MBS1398395-02 0.02 mg (Yeast)

Recombinant Gloeobacter violaceus Heat-inducible transcription repressor HrcA (hrcA)

Ask
View Details
Recombinant Gloeobacter violaceus Heat-inducible transcription repressor HrcA (hrcA)
MBS1398395-03 0.1 mg (E-Coli)

Recombinant Gloeobacter violaceus Heat-inducible transcription repressor HrcA (hrcA)

Ask
View Details