HER2 (phospho Tyr877) Antibody
Product Specifications
Background
Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.
NCBI Gene ID
2064
Swiss Prot
P04626
Accession Number
NP_001005862.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
HER2 (Phospho-Tyr877) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 877 (T-E-Y (p) -H-A) derived from Human HER2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
185 kDa
Specificity
This antibody detects endogenous level of HER2 only when phosphorylated at tyrosine 877.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Symbol
ERBB2
NCBI Official Name
V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
NCBI Organism
Homo sapiens
Background Reference 01
Dittadi, R. et al. (2000) J. Natl. Cancer Inst. 92, 1443-1444. Muthuswamy, S. K. et al. (1999) Mol. Cell. Biol. 19, 6845-6857. Qian, X. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 1500-1504.
Other Product Names
NEU, NGL, HER2, TKR1, CD340, HER-2, MLN19, HER-2/neu, BHLHE39, C-erbB-2, ErbB2
Tested Applications
WB, IHC, IF
Protein ID
54792098
Physical Properties
Liquid
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