JUN Antibody

V-jun avian sarcoma virus 17 oncogene homolog; Jun activation domain binding protein. The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. The JUN gene product has also been shown to be structurally and functionally identical to the enhancer binding protein, AP-1; thus AP-1 may be encoded by JUN. The JUN protein interacts directly with specific target DNA sequences to regulate gene expression. JUN has been mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.

JUN antibody can be stored at 4˚ C for short term (weeks) . Long term storage should be at -20˚ C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Eferl, R., Ricci, R., Kenner, L., Zenz, R., David, J. -P., Rath, M., Wagner, E. F. Liver tumor development: c-Jun antagonizes the proapoptotic activity of p53. Cell 112: 181-192, 2003.