MCP-1 Antibody [1A7B8]

Product Specifications

Background

Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH) . Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.

NCBI Gene ID

6347

Swiss Prot

P13500

Accession Number

P13500

Host

Mouse

Reactivity

Human

Immunogen

Ni-NTA purified recombinant human MCP-1 expressed in E.Coli strain BL21 (DE3) .

Clonality

Monoclonal

Clone

1A7B8

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

Antibody is purified by protein A affinity chromatography.

Concentration

Batch dependent

Buffer

Purified antibody in PBS containing 0.03% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

To MCP-1 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.