KSHVORF45 Antibody [2D4A5]
Product Specifications
Background
Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma- (2) -herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions.
NCBI Gene ID
4961474
Swiss Prot
F5HDE4
Accession Number
F5HDE4
Host
Mouse
Reactivity
Virus
Immunogen
Ni-NTA purified recombinant human KSHV ORF45 expressed in E. Coli strain BL21 (DE3) .
Clonality
Monoclonal
Clone
2D4A5
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Infectious Disease
Concentration
Batch dependent
Buffer
Ascitic fluid containing 0.03% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
To KSHV ORF45 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=32-228
Fragment
IgG1
Symbol
ORF45
NCBI Official Name
Virion phosphoprotein
NCBI Organism
Human herpesvirus 8
Background Reference 01
Chang Y. et al. 1994. Science. 266:1865-1869.
Background Reference 02
Zhu FX. et al. 2002. PNAS. 99: 5573-5578.
Background Reference 03
Zhu FX. et al. J Virol. 2003. April (77) : 4221-4230.
Other Product Names
Protein ORF45
Tested Applications
ELISA, WB
Protein ID
550540839
Curated Selection
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