IL-10 Antibody [3C12C12]
Product Specifications
Background
Interleukine 10 (IL-10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down- regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
NCBI Gene ID
3586
Swiss Prot
P22301
Accession Number
P22301
Host
Mouse
Reactivity
Human
Immunogen
Ni-NTA purified recombinant human IL-10 expressed in E. Coli strain BL21 (DE3) .
Clonality
Monoclonal
Clone
3C12C12
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Innate Immunity
Purification
Antibody is purified by protein A affinity chromatography.
Concentration
Batch dependent
Buffer
Purified antibody in PBS containing 0.03% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
To IL-10 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG1.kappa
Symbol
IL10
NCBI Official Name
Interleukin 10
NCBI Organism
Homo sapiens
Background Reference 01
Vieira P, et al. PNAS, 1991.88:1172-1176.
Other Product Names
Cytokine synthesis inhibitory factor, IL-10, CSIF, TGIF, GVHDS, IL10A
Tested Applications
ELISA, WB
Protein ID
124292
Curated Selection
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