SORL1 Antibody [3B6A9 / 3B6B11]
Product Specifications
Background
SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein) . SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.
NCBI Gene ID
6653
Swiss Prot
Q92673
Accession Number
Q92673
Host
Mouse
Reactivity
Human
Immunogen
Purified truncated recombinant SORL1-MBP expressed in E. Coli strain BL21 (DE3) .
Clonality
Monoclonal
Clone
3B6A9 / 3B6B11
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Concentration
Batch dependent
Buffer
Ascitic fluid containing 0.03% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SORL1 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=32-217
Fragment
IgG1
Symbol
SORL1
NCBI Official Name
Sortilin-related receptor, L (DLR class) A repeats containing
NCBI Organism
Homo sapiens
Background Reference 01
Scherzer CR. Offe K. Gearing M. et al. Arch Neurol. 2004, Aug, 61 (8) :1200-5.
Background Reference 02
Gabrielsson BG. Olofsson LE. Sjogren A. et al. Obes Res. 2005, Apr, 13 (4) :649-52.
Background Reference 03
Shah S. Yu G. Mol Interv. 2006, Apr, 6 (2) :74-6, 58. Review.
Other Product Names
C11orf32, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, LDLR relative with 11 ligand-binding repeats, LR11, LRP9, SORLA, gp250, SorLA-1, C11orf32
Tested Applications
ELISA, WB, IHC
Protein ID
296452912
Curated Selection
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