MCL1 Antibody [8C6D4B1]
Product Specifications
Background
Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.
NCBI Gene ID
4170
Swiss Prot
Q07820
Accession Number
NP_001184249.1
Host
Mouse
Reactivity
Human
Immunogen
Ni-NTA purified recombinant protein MCL-1expressed in E. Coli strain M15.
Clonality
Monoclonal
Clone
8C6D4B1
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Concentration
Batch dependent
Buffer
Purified antibody in PBS containing 0.03% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MCL-1 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=32-191
Fragment
IgG1
Symbol
MCL1
NCBI Official Name
Myeloid cell leukemia sequence 1 (BCL2-related)
NCBI Organism
Homo sapiens
Background Reference 01
Ota, N. et al. J. Hum. Genet. 2000. 46: 254-269.
Background Reference 02
Schwertfeger KL, Ryder JW, Anderson SM J Mammary Gland Biol Neoplasia 2000, 3 : 236-251.
Other Product Names
TM, EAT, MCL1L, MCL1S, Mcl-1, BCL2L3, MCL1-ES, bcl2-L-3, mcl1/EAT
Tested Applications
ELISA, WB, IHC
Protein ID
309747067
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
