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GLP Antibody [1B7B4]

Product Specifications

Background

Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L cells in response to ingested nutrients. The closely related peptides glucagon-like peptide (GLP-1) and glucagon have opposing effects on blood glucose. GLP-1 induces glucose-dependent insulin secretion in the pancreas, while glucagon stimulates gluconeogenesis and glycogenolysis in the liver. Glucagon is processed from a large precursor, proglucagon, in a tissue-specific manner in pancreatic alpha-cells. The identification of a hybrid peptide acting as both a GLP-1 agonist and a glucagon antagonist would provide a novel approach for the treatment of type 2 diabetes.

NCBI Gene ID

79813

Swiss Prot

Q9H9B1

Accession Number

Q9H9B1

Host

Mouse

Reactivity

Human

Immunogen

Ni-NTA purified truncated recombinant GLP expressed in E. Coli strain BL21 (DE3) .

Clonality

Monoclonal

Clone

1B7B4

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

Antibody is purified by protein A affinity chromatography.

Concentration

Batch dependent

Buffer

Purified antibody in PBS containing 0.03% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

GLP monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=32-161

Fragment

IgG1

Symbol

EHMT1

NCBI Official Name

Euchromatic histone-lysine N-methyltransferase 1

NCBI Organism

Homo sapiens

Background Reference 01

Clark Q. Pan, Joanne M. Buxton, Stephanie L. Yung, et al. J Biol Chem. 2006 Feb 27.

Background Reference 02

Michael F. Crutchlow, Jee-Young Nina Ham, et al. Int J Biochem Cell Biol. 2006;38 (5-6) :845-859.

Background Reference 03

Andrew Young Adv Pharmacol. 2005;52:151-71.

Other Product Names

EUHMTASE1, GLP, KIAA1876, KMT1D, Euchromatic histone-lysine N-methyltransferase 1, Eu-HMTase1, GLP1, FP13812, EUHMTASE1, bA188C12.1, RP11-188C12.1

Tested Applications

ELISA, WB

Protein ID

325511404

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