GLP Antibody [1B7B4]

Product Specifications

Background

Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L cells in response to ingested nutrients. The closely related peptides glucagon-like peptide (GLP-1) and glucagon have opposing effects on blood glucose. GLP-1 induces glucose-dependent insulin secretion in the pancreas, while glucagon stimulates gluconeogenesis and glycogenolysis in the liver. Glucagon is processed from a large precursor, proglucagon, in a tissue-specific manner in pancreatic alpha-cells. The identification of a hybrid peptide acting as both a GLP-1 agonist and a glucagon antagonist would provide a novel approach for the treatment of type 2 diabetes.

NCBI Gene ID

79813

Swiss Prot

Q9H9B1

Accession Number

Q9H9B1

Host

Mouse

Reactivity

Human

Immunogen

Ni-NTA purified truncated recombinant GLP expressed in E. Coli strain BL21 (DE3) .

Clonality

Monoclonal

Clone

1B7B4

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

Antibody is purified by protein A affinity chromatography.

Concentration

Batch dependent

Buffer

Purified antibody in PBS containing 0.03% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

GLP monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG1

Symbol

EHMT1

NCBI Official Name

Euchromatic histone-lysine N-methyltransferase 1

NCBI Organism

Homo sapiens

Background Reference 01

Clark Q. Pan, Joanne M. Buxton, Stephanie L. Yung, et al. J Biol Chem. 2006 Feb 27.

Background Reference 02

Michael F. Crutchlow, Jee-Young Nina Ham, et al. Int J Biochem Cell Biol. 2006;38 (5-6) :845-859.

Background Reference 03

Andrew Young Adv Pharmacol. 2005;52:151-71.

Other Product Names

EUHMTASE1, GLP, KIAA1876, KMT1D, Euchromatic histone-lysine N-methyltransferase 1, Eu-HMTase1, GLP1, FP13812, EUHMTASE1, bA188C12.1, RP11-188C12.1

Tested Applications

ELISA, WB

Protein ID

325511404

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