CTnI Antibody [3A10A12]
Product Specifications
Background
CTnI has an apparent molecular weight of 22.5 kDa. cTnI is a candidate marker with acceptable sensitivity and specificity for AMI and other cardiac diseases. Troponin, a molecule that binds to the thin filament (actin) of striated muscle fibers, acts with intracellular calcium to control the interaction of the thin filament with the thick filament (myosin), thus regulating muscle contraction. Troponin I prevents muscle contraction in the absence of calcium, which has two skeletal muscle isoforms with considerable amino acid sequence homology. cTnI contains an additional N-terminal sequence and is highly specific for myocardium.
NCBI Gene ID
7137
Swiss Prot
P19429
Accession Number
P19429
Host
Mouse
Reactivity
Human
Immunogen
Ni-NTA purified truncated recombinant cTnI expressed in E. Coli strain BL21 (DE3) .
Clonality
Monoclonal
Clone
3A10A12
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Concentration
Batch dependent
Buffer
Ascitic fluid containing 0.03% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CTnI monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG1
Symbol
TNNI3
NCBI Official Name
Troponin I type 3 (cardiac)
NCBI Organism
Homo sapiens
Background Reference 01
Cummins B and Cummins P, J Mol Cell Cardiol, 1987, 19 (10) :999-1010.
Background Reference 02
Cummins B, Auckland ML, and Cummins P, Am Heart J, 1987, 113 (6) :1333-44.
Background Reference 03
Darnell J, Lodish H, and Baltimore D, Molecular Cell Biology, New York, NY: Scientific American Books, 1986, 827-8.
Background Reference 04
Larue C, Defacque-Lacquemant H, Calzolari C, et al, Mol Immunol, 1992, 29 (2) :271-8.
Other Product Names
TNNC1, Cardiac troponin ICMH7, RCM1, cTnI, CMD2A, TNNC1, CMD1FF
Tested Applications
ELISA, WB, IHC
Protein ID
136213
Frequently Asked Questions
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