CTnI Antibody [3A10A12]

Product Specifications

Background

CTnI has an apparent molecular weight of 22.5 kDa. cTnI is a candidate marker with acceptable sensitivity and specificity for AMI and other cardiac diseases. Troponin, a molecule that binds to the thin filament (actin) of striated muscle fibers, acts with intracellular calcium to control the interaction of the thin filament with the thick filament (myosin), thus regulating muscle contraction. Troponin I prevents muscle contraction in the absence of calcium, which has two skeletal muscle isoforms with considerable amino acid sequence homology. cTnI contains an additional N-terminal sequence and is highly specific for myocardium.

NCBI Gene ID

7137

Swiss Prot

P19429

Accession Number

P19429

Host

Mouse

Reactivity

Human

Immunogen

Ni-NTA purified truncated recombinant cTnI expressed in E. Coli strain BL21 (DE3) .

Clonality

Monoclonal

Clone

3A10A12

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Concentration

Batch dependent

Buffer

Ascitic fluid containing 0.03% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CTnI monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG1

Symbol

TNNI3

NCBI Official Name

Troponin I type 3 (cardiac)

NCBI Organism

Homo sapiens

Background Reference 01

Cummins B and Cummins P, J Mol Cell Cardiol, 1987, 19 (10) :999-1010.

Background Reference 02

Cummins B, Auckland ML, and Cummins P, Am Heart J, 1987, 113 (6) :1333-44.

Background Reference 03

Darnell J, Lodish H, and Baltimore D, Molecular Cell Biology, New York, NY: Scientific American Books, 1986, 827-8.

Background Reference 04

Larue C, Defacque-Lacquemant H, Calzolari C, et al, Mol Immunol, 1992, 29 (2) :271-8.

Other Product Names

TNNC1, Cardiac troponin ICMH7, RCM1, cTnI, CMD2A, TNNC1, CMD1FF

Tested Applications

ELISA, WB, IHC

Protein ID

136213

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