AURKB Antibody [13E8D3]
Product Specifications
Background
AURKB (aurora kinase B, AIK2 or aurora-B), with 344-amino acid protein (about 39 kDa), localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB is a mitotic protein kinase, which phosphorylates histone H3 and regulates Chromosomal segregation during mitosis and meiosis.It may regulates several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis.Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. ARK-2 transcripts arepresent at high levels in human thymus and fetal liver.ARK-2 protein levels are maximal during both S and G2/M phases
NCBI Gene ID
9212
Swiss Prot
Q96GD4
Accession Number
Q96GD4
Host
Mouse
Reactivity
Human
Immunogen
Ni-NTA purified truncated recombinant AURKB expressed in E. Coli strain BL21 (DE3) .
Clonality
Monoclonal
Clone
13E8D3
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Concentration
Batch dependent
Buffer
Ascitic fluid containing 0.03% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
AURKB monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=32-114
Fragment
Isotype: IgG1
Symbol
AURKB
NCBI Official Name
Aurora kinase B
NCBI Organism
Homo sapiens
Background Reference 01
Song J et al. Immunity 22:621-31 (2005) .
Background Reference 02
Kapoor P et al. Mol Cell Biol 25:4934-45 (2005) .
Other Product Names
AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5, Aurora 1, AIM-1, AIK2, AurB, IPL1, PPP1R48, aurkb-sv1, aurkb-sv2
Tested Applications
ELISA, WB
Protein ID
317373473
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