Apoa5 (bd) Antibody [4H8H8E2 (c) ]
Product Specifications
Background
Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglyc erides, whereas a knock-in model with human ApoA5 produced 50–70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor-_ agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Recently, it was demonstrated that ApoA5 is present in human serum detected by polyclonal antibodies against both the NH2 and COOH termini, although at much lower concentration than other apolipoproteins.
NCBI Gene ID
116519
Swiss Prot
Q6Q788
Accession Number
Q6Q788
Host
Mouse
Reactivity
Human
Immunogen
Ni-NTA purified truncated recombinant human APOA5 expressed in E. Coli strain BL21 (DE3) .
Clonality
Monoclonal
Clone
4H8H8E2 (c)
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Concentration
Batch dependent
Buffer
Ascitic fluid containing 0.03% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Apoa5 (bd) monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=32-110
Fragment
IgG1
Symbol
APOA5
NCBI Official Name
Apolipoprotein A-V
NCBI Organism
Homo sapiens
Background Reference 01
Pennacchio, L. et al. Science 2001 294, 169-173.
Background Reference 02
Prieur, X. et al. (2003) J Biol Chem 278, 25468-25480.
Background Reference 03
Obrien, PJ. et al. (2005) Clin Chem 51:2, 1-9.
Other Product Names
RAP3, UNQ411/PRO773, Apolipoprotein A5, Apo-AV, RAP3, APOAV
Tested Applications
ELISA, WB
Protein ID
60391728
Curated Selection
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