4E-BP1 Antibody [9E12D9]
Product Specifications
Background
4E-BP1 (eukaryotic translation Initiation Factor 4E Binding Protein 1), also called ELF4EBP1/BP-1/PHAS-I , which is located on chromosome 8p12, with 118-amino acid protein (about 13 kDa) . Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the phosphorylation status of eIF4EBP1. Non phosphorylated eIF4EBP1 will bind strongly to eIF4E while (24 kDa), the phosphorylated form will not. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating eIF4EBP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the eIF4EBP1-eIF4E interaction.
NCBI Gene ID
1978
Swiss Prot
Q13541
Accession Number
Q13541
Host
Mouse
Reactivity
Human
Immunogen
Ni-NTA purified truncated recombinant 4EBP1 expressed in E. Coli strain BL21 (DE3) .
Clonality
Monoclonal
Clone
9E12D9
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Concentration
Batch dependent
Buffer
Ascitic fluid containing 0.03% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
4E-BP1 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG1
Symbol
EIF4EBP1
NCBI Official Name
Eukaryotic translation initiation factor 4E binding protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Pause, A. et al. 1994.Nature. 371:762–767.
Background Reference 02
Fadden, P. et al. 1997. J. Biol. Chem. 272:10240–10247.
Other Product Names
Phosphorylated heat- and acid-stable protein regulated by insulin 1, 4E-BP1, BP-1, 4EBP1, PHAS-I
Tested Applications
ELISA, WB
Protein ID
34921508
Curated Selection
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