SPR Antibody
Product Specifications
Background
SPR encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4) . Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.
NCBI Gene ID
6697
Swiss Prot
P35270
Accession Number
P35270
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This SPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the C-terminal region of human SPR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
28 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SPR
NCBI Official Name
Sepiapterin reductase
NCBI Organism
Homo sapiens
Background Reference 01
Leu-Semenescu, S., et al. Sleep 33 (3) :307-314 (2010) Schnetz-Boutaud, N.C., et al. Genes Brain Behav. 8 (8) :753-757 (2009) Clot, F., et al. Brain 132 (PT 7), 1753-1763 (2009)
Other Product Names
Sepiapterin reductase, SPR, SPR
Tested Applications
WB
Protein ID
464801
Physical Properties
Liquid
Frequently Asked Questions
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