HADHB Antibody

Product Specifications

Background

HADHB encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. Mutations in this gene result in trifunctional protein deficiency. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation.

NCBI Gene ID

3032

Swiss Prot

P55084

Accession Number

P55084

Host

Rabbit

Reactivity

Human

Immunogen

This HADHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315-342 amino acids from the C-terminal region of human HADHB.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

51 kDa

Fragment

Rabbit Ig

Symbol

HADHB

NCBI Official Name

Trifunctional enzyme subunit beta, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Purevsuren, J., et al. Mol. Genet. Metab. 98 (4) :372-377 (2009)

Background Reference 02

Bogenhagen, D.F., et al. J. Biol. Chem. 283 (6) :3665-3675 (2008)

Background Reference 03

Wang, R., et al. Zhonghua Fu Chan Ke Za Zhi 41 (10) :672-675 (2006)

Background Reference 04

Hillier, L.W., et al. Nature 434 (7034) :724-731 (2005)

Other Product Names

Trifunctional enzyme subunit beta, mitochondrial, TP-beta, 3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, HADHB

Tested Applications

WB, Flow

Protein ID

116241345

Physical Properties

Liquid

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