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GPR17 Antibody

Product Specifications

Background

Members of the G protein coupled receptor (GPCR) superfamily contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The organization of the GPR17 gene differs from that of many other GPCRs in that the open reading frame is distributed on 2 exons; an additional exon contains the 5 prime untranslated region. Human GPR17 is expressed as 2.3 and 6.3 kb mRNAs exclusively in brain. The 2 transcripts appear to represent alternatively polyadenylated variants. Based on protein sequence homology and the conservation of certain key residues, GPR17 appears to be closely related to the P2Y family of GPCRs. There are two nemed isoforms.

NCBI Gene ID

2840

Swiss Prot

Q13304

Accession Number

Q13304

Host

Rabbit

Reactivity

Human

Immunogen

This GPR17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-258 amino acids from the Central region of human GPR17.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=64-147

Calculated Molecular Weight

41 kDa

Fragment

Rabbit Ig

Symbol

GPR17

NCBI Official Name

Uracil nucleotide/cysteinyl leukotriene receptor

NCBI Organism

Homo sapiens

Background Reference 01

Pugliese, A.M., et al. Am. J. Physiol., Cell Physiol. 297 (4), C1028-C1040 (2009)

Background Reference 02

Parravicini, C., et al. BMC Bioinformatics 9, 263 (2008)

Background Reference 03

Ciana, P., et al. EMBO J. 25 (19) :4615-4627 (2006)

Other Product Names

Uracil nucleotide/cysteinyl leukotriene receptor, UDP/CysLT receptor, G-protein coupled receptor 17, P2Y-like receptor, R12, GPR17

Tested Applications

WB, IHC-P, Flow

Protein ID

21264435

Physical Properties

Liquid

Curated Selection

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