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STX1A Antibody

Product Specifications

Background

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein) -Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc) . Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis.

NCBI Gene ID

6804

Swiss Prot

Q16623

Accession Number

Q16623

Host

Rabbit

Reactivity

Human

Immunogen

This STX1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-57 amino acids from the N-terminal region of human STX1A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=64-127

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Symbol

STX1A

NCBI Official Name

Syntaxin-1A

NCBI Organism

Homo sapiens

Background Reference 01

Yoshida, T., et al. Int. J. Mol. Med. 24 (2) :233-246 (2009)

Background Reference 02

Hamdan, F.F., et al. Ann. Neurol. 65 (6) :748-753 (2009)

Background Reference 03

Corominas, R., et al. Neurosci. Lett. 455 (2) :105-109 (2009)

Background Reference 04

Chen, C.S., et al. J. Biol. Chem. 284 (11) :6877-6884 (2009)

Other Product Names

Syntaxin-1A, Neuron-specific antigen HPC-1, STX1A, STX1

Tested Applications

WB, IHC-P, Flow

Protein ID

2501084

Physical Properties

Liquid

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