ATP5A1 Antibody

Product Specifications

Background

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c) . This gene encodes the alpha subunit of the catalytic core.

NCBI Gene ID

498

Swiss Prot

P25705

Accession Number

P25705

Host

Rabbit

Reactivity

Human

Immunogen

This ATP5A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-503 amino acids from the C-terminal region of human ATP5A1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

60 kDa

Fragment

Rabbit Ig

Symbol

ATP5A1

NCBI Official Name

ATP synthase subunit alpha, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Pandey, N.R., et al. Am. J. Pathol. 175 (4) :1777-1787 (2009)

Background Reference 02

Seth, R., et al. J. Clin. Pathol. 62 (7) :598-603 (2009)

Background Reference 03

Law, I.K., et al. Proteomics 9 (9) :2444-2456 (2009)

Background Reference 04

Martins-de-Souza, D., et al. BMC Psychiatry 9, 17 (2009)

Other Product Names

ATP synthase subunit alpha, mitochondrial, ATP5A1, ATP5A, ATP5AL2, ATPM

Tested Applications

WB, IHC-P

Protein ID

114517

Physical Properties

Liquid

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