INSC Antibody
Product Specifications
Background
In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]) .
NCBI Gene ID
387755
Swiss Prot
Q1MX18
Accession Number
Q1MX18
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This INSC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 409-437 amino acids from the C-terminal region of human INSC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
63 kDa
Fragment
Rabbit Ig
Symbol
INSC
NCBI Official Name
Protein inscuteable homolog
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Vural, A., et al. Mol. Cell. Biol. 30 (6) :1528-1540 (2010)
Background Reference 03
Rivadeneira, F., et al. Nat. Genet. 41 (11) :1199-1206 (2009)
Background Reference 04
Izaki, T., et al. Biochem. Biophys. Res. Commun. 341 (4) :1001-1006 (2006)
Other Product Names
Protein inscuteable homolog, INSC
Tested Applications
WB, IHC-P
Protein ID
116248172
Physical Properties
Liquid
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