NEIL1 Antibody

Product Specifications

Background

NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]) .

NCBI Gene ID

79661

Swiss Prot

Q96FI4

Accession Number

Q96FI4

Host

Rabbit

Reactivity

Human

Immunogen

This NEIL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-159 amino acids from the Central region of human NEIL1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

44 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NEIL1

NCBI Official Name

Endonuclease 8-like 1

NCBI Organism

Homo sapiens

Background Reference 01

Zhao, X., et al. Biochemistry 49 (8) :1658-1666 (2010)

Background Reference 02

Forsbring, M., et al. Carcinogenesis 30 (7) :1147-1154 (2009)

Background Reference 03

Couve, S., et al. J. Biol. Chem. 284 (18) :11963-11970 (2009)

Background Reference 04

Muftuoglu, M., et al. J. Biol. Chem. 284 (14) :9270-9279 (2009)

Other Product Names

Endonuclease 8-like 1, 322-, DNA glycosylase/AP lyase Neil1, DNA- (apurinic or apyrimidinic site) lyase Neil1, Endonuclease VIII-like 1, FPG1, Nei homolog 1, NEH1, Nei-like protein 1, NEIL1