NEIL1 Antibody
Product Specifications
Background
NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]) .
NCBI Gene ID
79661
Swiss Prot
Q96FI4
Accession Number
Q96FI4
Host
Rabbit
Reactivity
Human
Immunogen
This NEIL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-159 amino acids from the Central region of human NEIL1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=64-067
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NEIL1
NCBI Official Name
Endonuclease 8-like 1
NCBI Organism
Homo sapiens
Background Reference 01
Zhao, X., et al. Biochemistry 49 (8) :1658-1666 (2010)
Background Reference 02
Forsbring, M., et al. Carcinogenesis 30 (7) :1147-1154 (2009)
Background Reference 03
Couve, S., et al. J. Biol. Chem. 284 (18) :11963-11970 (2009)
Background Reference 04
Muftuoglu, M., et al. J. Biol. Chem. 284 (14) :9270-9279 (2009)
Other Product Names
Endonuclease 8-like 1, 322-, DNA glycosylase/AP lyase Neil1, DNA- (apurinic or apyrimidinic site) lyase Neil1, Endonuclease VIII-like 1, FPG1, Nei homolog 1, NEH1, Nei-like protein 1, NEIL1
Tested Applications
WB
Protein ID
56404654
Physical Properties
Liquid
Curated Selection
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