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PEX12 Antibody

Product Specifications

Background

Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle.

NCBI Gene ID

5193

Swiss Prot

O00623

Accession Number

O00623

Host

Rabbit

Reactivity

Human

Immunogen

This PEX12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-158 amino acids from the Central region of human PEX12.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=64-021

Calculated Molecular Weight

41 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PEX12

NCBI Official Name

Peroxisome assembly protein 12

NCBI Organism

Homo sapiens

Background Reference 01

Zeharia, A., et al. J. Hum. Genet. 52 (7) :599-606 (2007)

Background Reference 02

Mano, S., et al. Plant J. 47 (4) :604-618 (2006)

Background Reference 03

Gootjes, J., et al. Hum. Mutat. 24 (2) :130-139 (2004)

Other Product Names

Peroxisome assembly protein 12, Peroxin-12, Peroxisome assembly factor 3, PAF-3, PEX12, PAF3

Tested Applications

WB

Physical Properties

Liquid

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