LFNG Antibody

Product Specifications

Background

LFNG belongs to evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This protein is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150) .

NCBI Gene ID

3955

Swiss Prot

Q8NES3

Accession Number

Q8NES3

Host

Rabbit

Reactivity

Human

Immunogen

This LFNG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human LFNG.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

42 kDa

Fragment

Rabbit Ig

Symbol

LFNG

NCBI Official Name

Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

NCBI Organism

Homo sapiens

Background Reference 01

Dunwoodie, S.L. Biochim. Biophys. Acta 1792 (2) :100-111 (2009)

Background Reference 02

Reedijk, M., et al. Int. J. Oncol. 33 (6) :1223-1229 (2008)

Background Reference 03

Sparrow, D.B., et al. Am. J. Hum. Genet. 78 (1) :28-37 (2006)

Background Reference 04

Cole, S.E., et al. Dev. Cell 3 (1) :75-84 (2002)

Other Product Names

Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, LFNG

Tested Applications

WB, IHC-P, Flow

Protein ID

27734417

Physical Properties

Liquid

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