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FANCC Antibody

Product Specifications

Background

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2) . The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This protein is for complementation group C.

NCBI Gene ID

2176

Swiss Prot

Q00597

Accession Number

Q00597

Host

Rabbit

Reactivity

Human

Immunogen

This FANCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-555 amino acids from the C-terminal region of human FANCC.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=63-986

Calculated Molecular Weight

63 kDa

Fragment

Rabbit Ig

Symbol

FANCC

NCBI Official Name

Fanconi anemia group C protein

NCBI Organism

Homo sapiens

Background Reference 01

Barroso, E., et al. Breast Cancer Res. Treat. 118 (3) :655-660 (2009)

Background Reference 02

McWilliams, R.R., et al. Cancer Epidemiol. Biomarkers Prev. 18 (9) :2549-2552 (2009)

Background Reference 03

Michiels, S., et al. Carcinogenesis 30 (5) :763-768 (2009)

Background Reference 04

Palmieri, R.T., et al. Cancer Epidemiol. Biomarkers Prev. 17 (12) :3567-3572 (2008)

Other Product Names

Fanconi anemia group C protein, Protein FACC, FANCC, FAC, FACC

Tested Applications

WB, IHC-P, IF, Flow

Protein ID

1706762

Physical Properties

Liquid

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