FANCC Antibody
Product Specifications
Background
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2) . The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This protein is for complementation group C.
NCBI Gene ID
2176
Swiss Prot
Q00597
Accession Number
Q00597
Host
Rabbit
Reactivity
Human
Immunogen
This FANCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-555 amino acids from the C-terminal region of human FANCC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
63 kDa
Fragment
Rabbit Ig
Symbol
FANCC
NCBI Official Name
Fanconi anemia group C protein
NCBI Organism
Homo sapiens
Background Reference 01
Barroso, E., et al. Breast Cancer Res. Treat. 118 (3) :655-660 (2009)
Background Reference 02
McWilliams, R.R., et al. Cancer Epidemiol. Biomarkers Prev. 18 (9) :2549-2552 (2009)
Background Reference 03
Michiels, S., et al. Carcinogenesis 30 (5) :763-768 (2009)
Background Reference 04
Palmieri, R.T., et al. Cancer Epidemiol. Biomarkers Prev. 17 (12) :3567-3572 (2008)
Other Product Names
Fanconi anemia group C protein, Protein FACC, FANCC, FAC, FACC
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
1706762
Physical Properties
Liquid
Frequently Asked Questions
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