HSD17B3 Antibody

Product Specifications

Background

This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.

NCBI Gene ID

3293

Swiss Prot

P37058

Accession Number

P37058

Host

Rabbit

Reactivity

Human

Immunogen

This HSD17B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-118 amino acids from the Central region of human HSD17B3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

35 kDa

Fragment

Rabbit Ig

Symbol

HSD17B3

NCBI Official Name

Testosterone 17-beta-dehydrogenase 3

NCBI Organism

Homo sapiens

Background Reference 01

Li, J., et al. Breast Cancer Res. 12 (2), R19 (2010)

Background Reference 02

Sata, F., et al.Sex Med (2010) In press

Background Reference 03

Ahn, J., et al. Hum. Mol. Genet. 18 (19) :3749-3757 (2009)

Background Reference 04

Chakrabarti, B., et al. Autism Res 2 (3) :157-177 (2009)

Other Product Names

Testosterone 17-beta-dehydrogenase 3, 17-beta-hydroxysteroid dehydrogenase type 3, 17-beta-HSD 3, Testicular 17-beta-hydroxysteroid dehydrogenase, HSD17B3, EDH17B3