NYX Antibody
Product Specifications
Background
The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB) . CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq].
NCBI Gene ID
60506
Swiss Prot
Q9GZU5
Accession Number
Q9GZU5
Host
Rabbit
Reactivity
Human
Immunogen
This NYX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-80 amino acids from the N-terminal region of human NYX.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
52 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NYX
NCBI Official Name
Nyctalopin
NCBI Organism
Homo sapiens
Background Reference 01
Leroy, B.P., et al. BrOphthalmol 93 (5) :692-696 (2009)
Background Reference 02
Zhang, Q., et al. Mol. Vis. 13, 330-336 (2007)
Background Reference 03
Morgans, C.W., et al. Eur. J. Neurosci. 23 (5) :1163-1171 (2006)
Background Reference 04
Xiao, X., et al. J. Hum. Genet. 51 (7) :634-640 (2006)
Other Product Names
Nyctalopin, NYX, CLRP
Tested Applications
WB
Protein ID
23396778
Physical Properties
Liquid
Curated Selection
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