CEBPA Antibody

Product Specifications

Background

CEBPA is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. This protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.

NCBI Gene ID

1050

Swiss Prot

P49715

Accession Number

P49715

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This CEBPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-330 amino acids from the C-terminal region of human CEBPA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

38 kDa

Fragment

Rabbit Ig

Symbol

CEBPA

NCBI Official Name

CCAAT/enhancer-binding protein alpha

NCBI Organism

Homo sapiens

Background Reference 01

Twu, Y.C., et al. Blood 115 (12) :2491-2499 (2010)

Background Reference 02

Nanri, T., et al. Genes Chromosomes Cancer 49 (3) :237-241 (2010)

Background Reference 03

Burnett, A.K., et al. Blood 115 (5) :948-956 (2010)

Background Reference 04

Dufour, A., et al. J. Clin. Oncol. 28 (4) :570-577 (2010)

Other Product Names

CCAAT/enhancer-binding protein alpha, C/EBP alpha, CEBPA

Tested Applications

WB, Flow

Protein ID

166898082

Physical Properties

Liquid

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