HAMP Antibody

Product Specifications

Background

HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.

NCBI Gene ID

57817

Swiss Prot

P81172

Accession Number

P81172

Host

Rabbit

Reactivity

Human

Immunogen

This HAMP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the Central region of human HAMP.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

9 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:500

Symbol

HAMP

NCBI Official Name

Hepcidin

NCBI Organism

Homo sapiens

Background Reference 01

Matsumoto, M., et al. Circ. J. 74 (2) :301-306 (2010)

Background Reference 02

Del Giudice, E.M., et al. J. Clin. Endocrinol. Metab. 94 (12) :5102-5107 (2009)

Background Reference 03

Kwapisz, J., et al.Zhejiang Univ Sci10 (11) :791-795 (2009)

Background Reference 04

Barton, J.C., et al. Am. J. Hematol. 84 (11) :710-714 (2009)

Other Product Names

Hepcidin, Liver-expressed antimicrobial peptide 1, LEAP-1, Putative liver tumor regressor, PLTR, Hepcidin-25, Hepc25, Hepcidin-20, Hepc20, HAMP, HEPC, LEAP1