FUT3 Antibody

Product Specifications

Background

FUT3 comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This protein is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha (1,3) -fucosyltransferase and alpha (1,4) -fucosyltransferase activities.

NCBI Gene ID

2525

Swiss Prot

P21217

Accession Number

P21217

Host

Rabbit

Reactivity

Human

Immunogen

This FUT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-315 amino acids from the C-terminal region of human FUT3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

42 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

FUT3

NCBI Official Name

Galactoside 3 (4) -L-fucosyltransferase

NCBI Organism

Homo sapiens

Background Reference 01

Park, H.D., et al. KoreanLab Med 30 (1) :51-57 (2010)

Background Reference 02

Matzhold, E.M., et al. Transfusion 49 (10) :2097-2108 (2009)

Background Reference 03

Norden, R., et al. Glycobiology 19 (7) :776-788 (2009)

Background Reference 04

Liu, J., et al. J. Exp. Clin. Cancer Res. 28, 154 (2009)

Other Product Names

Galactoside 3 (4) -L-fucosyltransferase, Blood group Lewis alpha-4-fucosyltransferase, Lewis FT, Fucosyltransferase 3, Fucosyltransferase III, FucT-III, FUT3, FT3B, LE