ADRA1B Antibody

Product Specifications

Background

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This protein encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This protein comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.

NCBI Gene ID

147

Swiss Prot

P35368

Accession Number

P35368

Host

Rabbit

Reactivity

Human

Immunogen

This ADRA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-297 amino acids from the Central region of human ADRA1B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

57 kDa

Fragment

Rabbit Ig

Symbol

ADRA1B

NCBI Official Name

Alpha-1B adrenergic receptor

NCBI Organism

Homo sapiens

Background Reference 01

Mathias, R.A., J. Allergy Clin. Immunol. 125 (2), 336-346 (2010)

Background Reference 02

Jensen, B.C., Circ Heart Fail (6), 654-663 (2009)

Background Reference 03

Gratacos, M., Am. J. Med. Genet.Neuropsychiatr. Genet. 150B (6), 808-816 (2009)

Other Product Names

Alpha-1B adrenergic receptor, Alpha-1B adrenoreceptor, Alpha-1B adrenoceptor, ADRA1B

Tested Applications

WB, IHC-P

Protein ID

116241241

Physical Properties

Liquid

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