CHIA Antibody

Product Specifications

Background

CHIA degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. There are 3 named isoforms produced by alternative splicing. CHIA is induced via a T helper-2 (Th2) -specific, interleukin-13-mediated pathway in epithelial cells and macrophages. CHIA may be an important mediator of IL13-induced responses in Th2-dominated disorders such as asthma. CHIA hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.

NCBI Gene ID

27159

Swiss Prot

Q9BZP6

Accession Number

Q9BZP6

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This CHIA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-47 amino acids from the N-terminal region of human CHIA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

52 kDa

Fragment

Rabbit Ig

Symbol

CHIA

NCBI Official Name

Acidic mammalian chitinase

NCBI Organism

Homo sapiens

Background Reference 01

Wu, A.C., et al. J. Allergy Clin. Immunol. 125 (3) :754-757 (2010)

Background Reference 02

Ober, C., et al. Curr Opin Allergy Clin Immunol 9 (5) :401-408 (2009)

Background Reference 03

Seibold, M.A., et al. J. Biol. Chem. 284 (29) :19650-19658 (2009)

Background Reference 04

Hartl, D., et al. J. Immunol. 182 (8) :5098-5106 (2009)

Other Product Names

Acidic mammalian chitinase, AMCase, Lung-specific protein TSA1902, CHIA

Tested Applications

WB, Flow

Protein ID

37999771

Physical Properties

Liquid

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