CROT Antibody

Product Specifications

Background

CROT encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.

NCBI Gene ID

54677

Swiss Prot

Q9UKG9

Accession Number

Q9UKG9

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This CROT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-79 amino acids from the N-terminal region of human CROT.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

70 kDa

Fragment

Rabbit Ig

Symbol

CROT

NCBI Official Name

Peroxisomal carnitine O-octanoyltransferase

NCBI Organism

Homo sapiens

Background Reference 01

Li, Y.L., et al. FEBS J. 276 (1) :303-314 (2009)

Background Reference 02

Morillas, M., et al. J. Biol. Chem. 277 (13) :11473-11480 (2002)

Background Reference 03

Van der Leij, F.R., et al. Mol. Genet. Metab. 71 (1-2), 139-153 (2000) :

Background Reference 04

Ferdinandusse, S., et al. Biochem. Biophys. Res. Commun. 263 (1) :213-218 (1999)

Other Product Names

Peroxisomal carnitine O-octanoyltransferase, COT, CROT, COT

Tested Applications

WB, IHC-P, Flow

Protein ID

48429265

Physical Properties

Liquid

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